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  • This technique can be applied for genome-wide mapping of DNA excision repair [52].
Cited in:Next-generation sequencing: hype and hope for development of personalized radiation therapy?2015info
Authors:Ingeborg TinhoferFranziska NiehrRobert KonschakSandra LiebsMatthias MunzAlbrecht StenzingerWilko WeichertUlrich KeilholzVolker Budach
DOI:10.1186/s13014-015-0481-x
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  • Furthermore, several recent studies have highlighted potential non-repressive roles of PERs and CRYs on the CLOCK:BMAL1 complexes [38, 39].
Cited in:A Novel Bmal1 Mutant Mouse Reveals Essential Roles of the C-Terminal Domain on Circadian Rhythms2015info
Authors:Noheon ParkHee dae KimSolmi CheonHansang RowJiyeon LeeDong hee HanSehyung ChoKyungjin Kim
DOI:10.1371/journal.pone.0138661
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  • EXO1 was expressed and purified as previously described (40,41).
  • UV-irradiation leads to accumulation of cyclobutane pyrimidine dimers (CPD) and 6–4 photoproducts (6–4PP) that are removed by the nucleotide excision repair machinery and the recruitment of RPA to the undamaged single-stranded DNA results in ATR activation (5).
Cited in:RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling2015(4962-4974)info
Authors:Ananya KarManpreet KaurTanushree GhoshMd Muntaz KhanAparna SharmaRitu ShekharAkhil VarshneySandeep Saxena
DOI:10.1093/nar/gkv369
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  • Nevertheless double mutant W397F/W536F proteins remain photo-inducible as measured by light induced proteolysis in a cell assay [46].
  • In addition, the W397F CRY mutant protein was effective in light induced TIM proteolysis even at fluences that do not photoreduce flavin [46].
  • These startling results reveal that photoreduction of flavin may not be the primary mechanism that provides CRY light signalling, even though FAD binding is essential [46].
  • However we should add that there is considerable debate at present on the relevance of the redox status of FAD for CRY light signalling [37], [42], [43], [46], [47].
  • In Drosophila melanogaster the CRY protein undergoes a conformational change after light absorption by its flavin component, allowing activated CRY to interact with Timeless (TIM) and others factors to promote TIM proteolysis, resulting in the resetting of the circadian clock [74].
  • However, the connection between internal circadian desynchronization (for example in shift workers) and cancer etiology remains unresolved and controversial15.
Cited in:Circadian Modulation of 8-Oxoguanine DNA Damage Repair2015info
Authors:Nicola ManzellaMassimo BracciElisabetta StrafellaSara StaffolaniVeronica CiarapicaAlfredo CopertaroVenerando RapisardaCaterina LeddaMonica AmatiMatteo ValentinoMarco TomasettiRichard G StevensLory Santarelli
DOI:10.1038/srep13752
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