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Genome-wide analysis of human global and transcription-coupled excision repair of UV damage at single-nucleotide resolution
Genes Dev Vol 29 (948-60)
Dual modes of CLOCK: BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock
Genes Dev Vol 28 (1989-1998)
J. Biol. Chem. Vol 289 (5074-5082)
- EXO1 was expressed and purified as previously described (40,41).
Cited in:The 9-1-1 checkpoint clamp stimulates DNA resection by Dna2-Sgs1 and Exo12014(10516-10528)info
- UV-irradiation leads to accumulation of cyclobutane pyrimidine dimers (CPD) and 6–4 photoproducts (6–4PP) that are removed by the nucleotide excision repair machinery and the recruitment of RPA to the undamaged single-stranded DNA results in ATR activation (5).
Mechanism of photosignaling by Drosophila cryptochrome: role of the redox status of the flavin chromophore
J. Biol. Chem. Vol 289 (4634-4642)
- Nevertheless double mutant W397F/W536F proteins remain photo-inducible as measured by light induced proteolysis in a cell assay .
- In addition, the W397F CRY mutant protein was effective in light induced TIM proteolysis even at fluences that do not photoreduce flavin .
- These startling results reveal that photoreduction of flavin may not be the primary mechanism that provides CRY light signalling, even though FAD binding is essential .
- However we should add that there is considerable debate at present on the relevance of the redox status of FAD for CRY light signalling , , , , .
Cited in:Genetic Analysis of Circadian Responses to Low Frequency Electromagnetic Fields in Drosophila melanogaster2014info
- In Drosophila melanogaster the CRY protein undergoes a conformational change after light absorption by its flavin component, allowing activated CRY to interact with Timeless (TIM) and others factors to promote TIM proteolysis, resulting in the resetting of the circadian clock .
Cited in:From Blue Light to Clock Genes in Zebrafish ZEM-2S Cells2014info
Vol 54 (110-123)